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The Use of Mercury Magnet in Heavy Metal ToxicityThe active ingredient in Mercury Magnet is a biopolymer with molecular weights ranging between 25 - 45 K. The active ingredient is isolated from the bark of a particular species of oak tree that is native to forests in Eastern Europe. It is chemically a poly phenolic acid, with molecular structures that resemble procyanins. Oral administration of Mercury Magnet is safe, although some unpleasant gastrointestinal side effects (excess gastric acid secretion and gas formation) may develop, although rarely (approximately 1 % to 2%), and termination of Mercury Magnet is recommended. As evidenced by radio- labeled Mercury Magnet in animal studies, Mercury Magnet does not get absorbed. No traces of the active ingredient were found in the blood- stream, but rather completely secreted in the feces (which is most likely due to the high molecular weight of the active ingredient).
Study I (Human with lead toxicity)Volunteer workers of the Ajka Crystal Factory (Hungary) ranging from 18 to 60 years old of both sexes, who had been continually exposed to high doses of lead prior to starting the trial, were selected. The workers' blood lead level was regularly determined during the mandatory blood lead control exams that were carried out every six months. Volunteers, whose blood lead levels exceeded 2.4 umol/l by the end of the third week, were removed from their workplace and employed in a less risky job, until their blood level dropped below 2.5 umo/l. In the case of young female workers the critical threshold was 15 11 - umol/I The following criteria were set for exclusion from the study group:
60 volunteers were selected to participate in the study. Results and Test ProtocolOut of the 60 participants, 2 volunteers stopped taking Mercury Magnet due to uncomfortable feeling around the stomach (excess gas and acid secretion). 58 volunteers completed the 12? - week study. The duration of the trial (the treatment period for one patient) was 12 weeks. The volunteer glass factory workers, who had participated in the obligatory serum lead screening examinations and met the criteria for participation, reported for the trial at the factory medical clinic. On the first day of the research program personal histories were taken from each participant. Each participant underwent a physical check- up that included an ECG, blood pressure and heart rate monitoring, and laboratory tests. The volunteers involved in the trial were given the Mercury Magnet in a syrup in sufficient quantities for a three- week treatment protocol. They took 1 x 10 ml syrup per day after the main meal in accordance with the instructions on administration. Control examinations were held on the 42" and the 84th (±3 days) days. The volunteers appearing for control examination participated in laboratory tests, which according to the protocol - comprised of the following examinations:
In the entire test population - consisting of 58 individuals - Se (serum) lead dropped in 46 patients compared to the initial parameters, which indicates a 79.3% positive reaction to Mercury Magnet (as shown after statistical analysis of the data). The volunteers were divided into two groups (a and b); the members of group "a" were exposed to lead throughout the trial, whereas those of group "b" the exposure was interrupted. By the end of the therapy (12 - week duration), the mean blood lead level lowered in the entire group of volunteers by 0.18 umol/dm3, while in the group exposed to lead all through the trial the reduction was 0.12 umol/dm3. In the group removed from exposure it was by 0.26 umol/dm3. The rate of reduction was significant in all three groups cases Final Comments and DiscussionThe key selection criteria included exposure and a minimum blood lead level of 1 umol/dm3 as specified in the protocol. Relocation from the workplace was a necessity, as it was obligatory to stop exposure whenever the limit value defined by OMFI and ANTSZ was exceeded. The same way re- employment was allowed when the measured parameter dropped below the normal limit. Lead as a heavy metal, when it is taken up by the organism, gets deposited in parenchymal organs and the bone. It competes with Se Fe and causes iron deficiency anemia in those exposed to lead. It might even damage the nervous system. ZnPP accumulation serves as a rough preliminary indicator. It has been observed that the increase of Se lead level follows that of the ZnPP level by an interval of 3- 5 months, although there are large differences due to individual sensitivity. Several years of monitoring have shown that those, who were included in the trial group, are of the so- called "fast take- up" and "slow discharge" kind. The higher WBC and St % found in Laboratory 1 can be considered as a reaction of the bone marrow. The higher liver enzyme partial values measured in group "b" in Laboratory II also confirm the heavy charge on the parenchymal organ. Compared to initial values the higher Hgb, MCH, MCHC and St % increase indicate the regeneration of bone marrow - obviously because of the chelate- like lead binding capability of available iron in Mercury Magnet. The reduction of Se cholesterol seems also interesting and deserves to be followed up. The same way the reduction of SGOT and SGPT level is also noteworthy. It might confirm that Mercury Magnet by eliminating the lead deposited in the liver facilitates the normalization of the enzyme level.
Study II (human - cadmium)Based on the metal chelating capacity of Mercury Magnet and the well- known interaction of cadmium with other micro/trace elements, this study was aimed at determining whether the daily consumption of Mercury Magnet with bound complex micro elements (1MB) has beneficial effect in cadmium workers. Blood and urine cadmium concentrations (Cd- B and Cd- U), hematology, liver and kidney tests were measured in two groups of cadmium exposed workers (Group A: 9 persons working in alkaline battery production; Group B: 22 persons working in a metal plating workshop) before and after a six- week treatment schedule. Cd- B was significantly decreased in group A from 47.73 to 27.24 umol/l (43% drop) and in group B from 8.55 to 7.17 umol/l (17% drop). Cd- U was increased significantly in group A from 3.21 to 4.25 nmol/mmol creatinine but not in group B. In most cases the initially abnormal serum iron levels and markers of liver and kidney function improved. Daily consumption of IME for six weeks seemed to decrease uptake and increase urinary excretion of cadmium and to improve the iron status and other adverse laboratory changes found in the workers. Regular consumption of IME may contribute to health protection an effective means of prevention and in cases of occupational cadmium exposure.
Administration of Mercury Magnet (MB) during the study: 10 ml taken orally once a day (supplemented with potassium: 36.7 mg, magnesium: 15 mg, iron: 14 mg, zinc: 10 mg, manganese: 3 mg, copper: 2 mg, vanadium: 0.5 mg, cobalt: 0.2 mg, molybdenum: 0.175 mg, selenium: 0.125 mg, that does not exceed the respective recommended daily intake for any element; WHO, 1992). Venous blood and spot urine samples were analyzed.
Figure 1. Decrease of blood cadmium concentration in Group A workers (alkaline battery plant) on the effect of consumption of IME for six weeks F: female.
Figure 2. Changes of blood cadmium concentration in group B workers (metal plating factory) on the effect of consumption of IME for six weeks. F: female.
Figure 3. Increase of urine cadmium concentration in Group A (alkaline battery plant – except No. 10) on the effect of consumption of IME for six weeks. F: female.
Figure 4. Increase of serum iron concentration in cadmium exposed workers with initial sideropenia on the effect of consumption of IME for six weeks. A: Group A; F: female.
In summary, daily consumption of IMIE (Mercury Magnet plus supplemented metals, see above) for six weeks decreased Cd- Blood and increased Cd- Urine in workers continuously exposed to cadmium. Thus, 1MB seemed to decrease the uptake and increase the urinary excretion of cadmium. In addition, it improved the iron status and the other adverse laboratory changes detected as a result of cadmium intoxication. Consumption of 1MB may be an effective means of health protection and may contribute to prevention of adverse health effects in occupational cadmium exposure. Study III (Animal - Mercury)Contaminating substance: mercury(II) chloride labeled with Hg isotope in aqueous solution. For mercury administration 1000 ml solution with approximately 50 kBq/ml activity concentration and 0.09 mg/ml mercury concentration was made using the isotope preparation detailed above, common mercury(II) chloride and distilled water. Test substance: Mercury Magnet syrup preparation supplemented with metals (see above). Trial livestockSpecies and strain:pig; Hungarian White Large x Pietrain Source:Ecsenyi Agricultural Co. Justification of species:It is a suitable model animal for the extrapolation of research results for human clinical trials. Sex:male Age of animals:between 60 and 65 days Weight range at the beginning of the trial: 16.2- 18.2 kg (35.6- 40.4 lb) Number of animals:15 Only healthy animals, as certified by a veterinary surgeon, were used in the trials. The animals were divided into four groups according to the treatment protocols: 4, 4, 4 and 3 pigs in group I, II, IV and III, respectively. Cages of standard size allowed separate feces and urine collection. Light:artificial (only during the day) Temperature:18- 26°C Relative humidity:65- 75% Animal space:0.60m x 0.35m = 0.21 m2 (per animal) Food and feedThe animals received MT- 10 standard diet produced by Déldunántuli Gabona Rt. (DelDunántul Grain Co.), ad libitum. Water supplyThe animals received ordinary tap water ad libitum daily. Animal identificationThe animals were identified by ear tags. Administration of the contaminating substanceOn the day following the five- day acclimation period, each pig received 10 ml of the radioactive HgC12 solution prepared according to the description in paragraph 3.1. in order that mercury loss is prevented, the mercury solution was added to feed of a certain quantity, then the produced mixture was fed separately. In this manner 0.9 mg mercury (900 ug is a 5- fold increase of mercury from 1992 vaccine protocol) labeled with 203 Hg isotope of 503.9 kBq activity was administered to each animal. Treatment protocolsEvery day including the five days of the acclimation period, the Mercury Magnet intake was zero, 2.5, 7.5 and 20 ml/pig/day for group I, II, III and IV respectively. Mercury Magnet was dissolved in the morning drinking water (for Groups II, III and IV). Mercury measurementThe radioactivity the 203 Hg isotope was determined in feces and urine daily and also in organs after slaughter. Data were subjected to statistical analysis. ResultsTable 1
Note: Control animals excreted 64.9% (584.4 ug) of mercury. Table 2 Specific activity (Hg content) of pig organs on the 1 Id day after mercury administration (Bq/g)
Mercury Magnet resulted in a significant increase in mercury(II) excretion in pigs, as evidenced by the appearance of Hg activity mostly in the urine. It also appeared to decrease mercury levels in all organs examined, although high level significance (P<O.05) was only observed for kidney, lung and brain. Please note this is an 87% reduction of mercury in the brain as compared to controls. Bibliography Personal communication, Department of Biochemistry, University of Kaposvar, Kaposvar, Hungary. Required Disclaimer These statements have not been evaluated by the U.S. FDA or Health Canada. This information is provided as an educational service and should not be considered advice on taking or using Mercury Magnet or other nutrients to diagnose, treat, prevent or cure any disease.
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